Ultrasonic Sound Effects Mice – University Case Study
University case study involving ultrasound-induced defense reactions in mice.
© 2011 American College of NeuropsychopharmacologySevere Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons: Neural and Behavioral Consequences
Key abbreviation: US meaning Ultrasound
Summary
In an aversive ultrasound-induced defense paradigm, mice displayed a major increase in ‘wild’ escape-like behaviors.
Study keywords include depression; anxiety; defense behaviors. (Page 1 )
Mice were tested for their innate fear reactions to a train of ultrasonic stimuli (US) … Animals were placed one per cage for at least 1 week before testing. In brief, 100 ms frequency sweeps between 17 and 20 kHz, 85 dB, alternately ON 2 seconds and then OFF 2 seconds for 1 min were delivered into the home cage (10 × 29 cm2) after a 3-min baseline period. Flight reactions triggered during ON periods were measured as the number of running events from one side of the cage to the other followed by behavioral arrest, whereas the percentage time ‘freezing’ to the US stimuli was quantified by sampling events of complete immobility (except respiration) every 4 [seconds] during the OFF period. These defense behaviors were measured from a video file by an observer unaware of mouse genotype.
(Page 3 )
This diagram shows the inverse relationship between brain tissue levels of 5-HT and aversive ultrasound-induced flight behaviors in mice. There was an enhancement of flight behaviors in reaction to the aversive ultrasound (1 min fast sweep 17–20 kHz, 85 dB) in [these] mice compared with control mice, which was reversed by a chronic treatment with pargyline.
(Page 9 )
Nicolas Narboux-Nême, Corinne Sagné, Stephane Doly, Silvina L Diaz, Cédric B P Martin, + et al.
Neuropsychopharmacology 36, 2538–2550 doi:10.1038/npp.2011.142
Recent Articles
-
Plants vs Deer!
We have created a list of plants that you can include in your garden that will not only keep the deer away, but some repel mosquitoes too! -
Spiders, Bats, and Bees... OH MY!
Let’s talk environment for a minute, particularly the benefits of bats, bees and spiders to our ecosystem. -
Caution … It’s Tick Season!
It is that time of year again, Summer is here and that means tick season too. Ticks can carry dangerous diseases that can severely harm you, your family and your beloved pets. Knowing how to properly remove ticks and being aware of the signs and symptoms of infection can help prevent life threatening illnesses. -
Repel Pests with the Help of Essential Oils
Essential oils are a natural ingredient that can easily be used to repel pests, such as mice and insects. While we find their scents pleasant, the pests do not! -
Luck of the Monarch
Whether big or small, your outdoor spaces can be a delight for you and the butterflies. Bring out the “welcome mat” by growing flowers that attract these beauties with their nectars.
